{"id":164,"date":"2023-11-15T01:00:27","date_gmt":"2023-11-14T22:00:27","guid":{"rendered":"https:\/\/cholesterol-lowering-info.com\/blog\/?p=164"},"modified":"2023-11-06T22:46:39","modified_gmt":"2023-11-06T19:46:39","slug":"gm2-gangliosidosis-type-ii-sandhoff-disease","status":"publish","type":"post","link":"https:\/\/cholesterol-lowering-info.com\/blog\/2023\/11\/15\/gm2-gangliosidosis-type-ii-sandhoff-disease\/","title":{"rendered":"GM2 Gangliosidosis Type II (Sandhoff Disease)"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-169\" src=\"https:\/\/cholesterol-lowering-info.com\/blog\/wp-content\/uploads\/2023\/11\/cholesterol-lowering-info_11.jpg\" alt=\"\" width=\"440\" height=\"310\" srcset=\"https:\/\/cholesterol-lowering-info.com\/blog\/wp-content\/uploads\/2023\/11\/cholesterol-lowering-info_11.jpg 440w, https:\/\/cholesterol-lowering-info.com\/blog\/wp-content\/uploads\/2023\/11\/cholesterol-lowering-info_11-300x211.jpg 300w\" sizes=\"(max-width: 440px) 100vw, 440px\" \/><\/h2>\n<h2>What is Gangliosidosis GM2 Type II (Sandhoff Disease)?<\/h2>\n<p><strong>Gangliosidosis GM2 type II (Sandhoff&#8217;s Disease)<\/strong> is a hereditary disease from the group of gangliosidosis.<\/p>\n<h2>Causes of Gangliosidosis GM2 Type II (Sandhoff Disease)<\/h2>\n<p>Sandhoff&#8217;s disease (GM2-gangliosidosis, type II, option 0) develops as a result of partial deficiency of hexosaminidase A.<\/p>\n<h2>Pathogenesis during gangliosidosis GM2 Type II (Sandhoff Disease)<\/h2>\n<p>Characteristic is the swelling of neurons with concentric layers of cytoplasmic inclusions, but with type II there is a higher concentration of aspaloganglioside GM2 in the nervous tissue, as well as glycosphingolipid in the mesenchymal tissues of internal organs, which is manifested by insignificant hepatomegaly.<\/p>\n<h2>Symptoms of Gangliosidosis GM2 Type II (Sandhoff Disease)<\/h2>\n<p>Begins at the age of 2-6 years with ataxia. Tetraparesis, mental deterioration, atrophy of the optic nerves, the symptom of &#8220;cherry bone&#8221; and retinal pigment degeneration appear gradually. In GM2-gangliosidosis (variant AB), the activity of galactosaminidases A and B is normal, but there is an accumulation of GM2 ganglioside in the brain. This form is A. and. begins at the age of about 1 year with the appearance of muscle hypotension, seizures. Decerebration rigidity gradually develops, a \u201ccherry bone\u201d symptom appears in the fundus. Death occurs at the age of 3 years.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is Gangliosidosis GM2 Type II (Sandhoff Disease)? Gangliosidosis GM2 type II (Sandhoff&#8217;s Disease) is a hereditary disease from the group of gangliosidosis. Causes of Gangliosidosis GM2 Type II (Sandhoff Disease) Sandhoff&#8217;s disease (GM2-gangliosidosis, type<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/posts\/164"}],"collection":[{"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/comments?post=164"}],"version-history":[{"count":2,"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/posts\/164\/revisions"}],"predecessor-version":[{"id":170,"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/posts\/164\/revisions\/170"}],"wp:attachment":[{"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/media?parent=164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/categories?post=164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cholesterol-lowering-info.com\/blog\/wp-json\/wp\/v2\/tags?post=164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}